RESEARCH ON PREPARATION OF Plectranthus amboinicus EFFERVESCENT TABLETS

Abstract

Plectranthus amboinicus leaves contain 0.05-0.12% essential oil with many pharmacological properties including antibacterial, anti-inflammatory, analgesic, anti-cancer, wound-healing, antioxidant. However, essential oil from P. amboinicus leaves has a rather unpleasant taste for some people, especially children. When effervescent tablets of P. amboinicus dissolve in water, NaHCO3 reacts organic acids to produce CO2 gas, that create a tingling sensation on the tongue, helping to reduce the unpleasant taste of the leaves. This study aimed to determine the optimal technical parameters of the vacuum concentration process and the composition of ingredients to create effervescent tablets from vacuum concentrated extract of P. amboinicus. The results of the study showed that the optimal technical parameters for creating effervescent tablets from P. amboinicus extract are as follows: the vacuum concentration temperature and time was 60 ℃ and 2.5 hours, respectively; The ingredients used to create effervescent tablets include: citric acid 5%, NaHCO3 15%, sucrose 30%, maltodextrin 15% and vacuum-concentrated extract of P. amboinicus 35%. Dissolution time of the tablet was 2.7 minutes. The hardness of the tablet was 3 kg. The essential oil content per tablet was 80 mg. The effervescent tablets had a pleasant taste and were accepted by consumers.